Variations in linear energy transfer within clinical proton therapy fields and the potential for biological treatment planning.

@article{Grassberger2011VariationsIL,
  title={Variations in linear energy transfer within clinical proton therapy fields and the potential for biological treatment planning.},
  author={Clemens Grassberger and Alexei Trofimov and Anthony Lomax and Harald Paganetti},
  journal={International journal of radiation oncology, biology, physics},
  year={2011},
  volume={80 5},
  pages={1559-66}
}
PURPOSE To calculate the linear energy transfer (LET) distributions in patients undergoing proton therapy. These distributions can be used to identify areas of elevated or diminished biological effect. The location of such areas might be influenced in intensity-modulated proton therapy (IMPT) optimization. METHODS AND MATERIALS Because Monte Carlo studies to investigate the LET distribution in patients have not been undertaken so far, the code is first validated with simulations in water. The… CONTINUE READING