Variations in dietary iron alter brain iron metabolism in developing rats.

@article{Pinero2000VariationsID,
  title={Variations in dietary iron alter brain iron metabolism in developing rats.},
  author={Domingo J. Pinero and Nianbin Li and James R. Connor and John L. Beard},
  journal={The Journal of nutrition},
  year={2000},
  volume={130 2},
  pages={254-63}
}
The rat has been widely used as a model for the study of iron deficiency (ID), but the differences in the timing of development of humans and rats must be taken into account to derive appropriate conclusions from the animal model. This study was designed to evaluate the effects of dietary ID and iron excess on rat brain iron and the iron metabolism proteins, transferrin (Tf), transferrin receptor (TfR) and ferritin. The experimental design is developmentally sensitive and permits control of the… CONTINUE READING