Variations in GABRA2, encoding the alpha 2 subunit of the GABA(A) receptor, are associated with alcohol dependence and with brain oscillations.

@article{Edenberg2004VariationsIG,
  title={Variations in GABRA2, encoding the alpha 2 subunit of the GABA(A) receptor, are associated with alcohol dependence and with brain oscillations.},
  author={Howard J. Edenberg and Danielle M Dick and Xiaoling Xuei and Huijun Tian and Laura Almasy and Lance O. Bauer and Raymond R. Crowe and Alison M. Goate and Victor M. Hesselbrock and Kevin A Jones and Jennifer M Kwon and T K Li and John J I Nurnberger and Sean J. O'Connor and Theodore Reich and John P. Rice and Marc A Schuckit and Bernice Porjesz and Tatiana Foroud and H. Begleiter},
  journal={American journal of human genetics},
  year={2004},
  volume={74 4},
  pages={705-14}
}
Alcoholism is a complex disease with both genetic and environmental risk factors. To identify genes that affect the risk for alcoholism, we systematically ascertained and carefully assessed individuals in families with multiple alcoholics. Linkage and association analyses suggested that a region of chromosome 4p contained genes affecting a quantitative endophenotype, brain oscillations in the beta frequency range (13-28 Hz), and the risk for alcoholism. To identify the individual genes that… CONTINUE READING
Highly Influential
This paper has highly influenced 34 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
Recent Discussions
This paper has been referenced on Twitter 1 time over the past 90 days. VIEW TWEETS
271 Citations
52 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 271 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 52 references

Similar Papers

Loading similar papers…