Variations in CD4 expression by human monocytes and macrophages and their relationships to infection with the human immunodeficiency virus.

@article{Kazazi1989VariationsIC,
  title={Variations in CD4 expression by human monocytes and macrophages and their relationships to infection with the human immunodeficiency virus.},
  author={F Kazazi and Jules Mathijs and Patricia Foley and Anthony L Cunningham},
  journal={The Journal of general virology},
  year={1989},
  volume={70 ( Pt 10)},
  pages={2661-72}
}
The expression of CD4 antigen on the surface of LeuM3-positive human blood monocytes was found to be variable with 65 to 90% of cells from 46 normal human volunteers being positive by dual staining flow cytometry. When monocytes adhered to plastic (but not when cultured on Teflon), a marked decrease in CD4 expression was observed between 1 and 24 h post-adherence. CD4 expression could not be detected in macrophages adhered to plastic for 5 days by using four anti-CD4 monoclonal antibodies in… CONTINUE READING