Variations and mutations in the hepatitis B virus genome and their associations with clinical characteristics.

@article{Yano2015VariationsAM,
  title={Variations and mutations in the hepatitis B virus genome and their associations with clinical characteristics.},
  author={Yoshihiko Yano and Takeshi Azuma and Yoshitake Hayashi},
  journal={World journal of hepatology},
  year={2015},
  volume={7 3},
  pages={583-92}
}
Hepatitis B virus (HBV) infection is major global issue, because chronic HBV infection is strongly associated with liver cancer. HBV spread worldwide with various mutations and variations. This variability, called quasispecies, is derived from no proof-reading capacity of viral reverse transcriptase. So far, thousands of studies reported that the variety of genome is closely related to the geographic distribution and clinical characteristics. Recent technological advances including capillary… CONTINUE READING