Variation of serum uric acid levels in multiple sclerosis during relapses and immunomodulatory treatment
@article{Guerrero2008VariationOS, title={Variation of serum uric acid levels in multiple sclerosis during relapses and immunomodulatory treatment}, author={{\'A}ngel Luis Guerrero and J. Mart{\'i}n-Polo and E. Laherr{\'a}n and Fernando Guti{\'e}rrez and Fernando Iglesias and Maria A. Tejero and Manuel Rodr{\'i}guez-Gallego and C Del Moral Alcazar}, journal={European Journal of Neurology}, year={2008}, volume={15} }
Uric acid (UA), a product of purine metabolism, may be an antioxidant, perhaps acting as a scavenger of peroxynitrite. Patients with gout have a reduced incidence of multiple sclerosis (MS). A number of studies found that patients with MS have low serum levels of UA, although it has not been established whether this represents a primary deficit or a secondary effect. UA has also been proposed as a marker of disease activity and response to immunosuppressive or immunomodulatory treatment. We…
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Serum Uric Acid Levels in Patients with Relapsing-Remitting Multiple Sclerosis
- Medicine, Biology
- 2009
Serum UA levels did not correlate with clinical activity, EDSS score and disease duration either in relapse or remitting or both of them, and suggests serum uric acid levels may affect neither pathogenesis of MS nor activity of disease.
Serum uric acid levels in multiple sclerosis patients inversely correlate with disability
- Psychology, MedicineNeurological Sciences
- 2011
This is the first description of an inverse correlation of serum UA levels with disability as assessed by EDSS score, which is associated with clinical relapse in multiple sclerosis patients.
Association of serum bilirubin and uric acid levels changes during neuroinflammation in patients with initial and relapsed demyelination attacks
- Medicine, BiologyMetabolic Brain Disease
- 2013
The obtained results point to the importance of endogenous antioxidants in the outbreak and course of neuroinflammation and could be favorable for the new pathogenetically conditioned neuroinflammatory therapy concepts.
Serum uric acid levels in patients with multiple sclerosis: a meta-analysis
- Medicine, BiologyNeurological research
- 2012
The study suggests that UA is relevant to MS, and whether the administration of UA levels by inosine might be considered as a novel treatment strategy for MS is needed.
Low Serum Urate Levels Are Associated to Female Gender in Multiple Sclerosis Patients
- Medicine, BiologyPloS one
- 2012
The findings suggest that low urate levels could be of significance in predominantly inflammatory phases of MS even at the early stage and mainly in females.
Cerebrospinal fluid and serum uric acid levels in patients with multiple sclerosis
- Medicine, BiologyClinical chemistry and laboratory medicine
- 2009
The results support the significance of UA in the pathogenesis of multiple sclerosis and suggest CSF UA concentrations may not be a reliable marker of disease activity in MS since its concentration is dependent on leakage of UA molecules from serum through the damaged BBB and the balance between consumption/production within the central nervous system (CNS).
Serum Metabolic Profile in Multiple Sclerosis Patients
- BiologyMultiple sclerosis international
- 2011
The concomitant increase in circulating creatinine, malondialdehyde, nitrite, and nitrate, and decrease in ascorbic acid demonstrates that MS induces alteration in energy metabolism and in oxidants/antioxidants balance that can be monitored in serum of MS patients.
Influence of serum uric acid levels on prognosis and survival in amyotrophic lateral sclerosis: a meta-analysis
- Biology, PsychologyJournal of Neurology
- 2014
A meta-analysis of published studies comparing UA levels between ALS patients and controls revealed highly statistically significant lower UA levels in patients compared to controls, with very large total size effect, more prominent in men.
Boosting endogenous neuroprotection in multiple sclerosis: the ASsociation of Inosine and Interferon β in relapsing- remitting Multiple Sclerosis (ASIIMS) trial
- Medicine, BiologyMultiple sclerosis
- 2010
It is concluded that endogenous neuroprotective mechanisms recently identified in multiple sclerosis are complex and uric acid does not reflect the entire story and interferon β alone alone did not provide any additional benefit on accumulation of disability.
Reduced serum uric acid levels in neuromyelitis optica: serum uric acid levels are reduced during relapses in NMO
- Biology, MedicineActa neurologica Scandinavica
- 2012
The aim of this study was to investigate the association between serum UA levels and disease activity in neuromyelitis optica.
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