Variation of human natural killer cell phenotypes with age: identification of a unique KLRG1-negative subset.

@article{Hayhoe2010VariationOH,
  title={Variation of human natural killer cell phenotypes with age: identification of a unique KLRG1-negative subset.},
  author={Richard P G Hayhoe and Sian M. Henson and Arne N. Akbar and Donald B. Palmer},
  journal={Human immunology},
  year={2010},
  volume={71 7},
  pages={676-81}
}
Human natural killer (NK) cells subsets are phenotypically characterized by their lack of CD3 and low/high expression of CD56. This study revealed an age-associated increase in the ratio of CD3(-)CD56(dim) to CD3(-)CD56(bright) NK cells, whereas distinct expression patterns of CD2, CD16, CD57, and the C-type lectin family members killer cell lectin-like receptor -D1 (CD94) and -G1 (KLRG1), were noted on both these NK and the CD3(+)CD56(+) T cell subsets; moreover, CD94 and KLRG1 expression were… CONTINUE READING

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