Variation of gene-based SNPs and linkage disequilibrium patterns in the human genome.

@article{Tsunoda2004VariationOG,
  title={Variation of gene-based SNPs and linkage disequilibrium patterns in the human genome.},
  author={Tatsuhiko Tsunoda and G. M. Lathrop and Akihiro Sekine and Ryo Yamada and Atsushi Takahashi and Yozo Ohnishi and Toshihiro Tanaka and Yusuke Nakamura},
  journal={Human molecular genetics},
  year={2004},
  volume={13 15},
  pages={1623-32}
}
A principal goal in human genetics is to provide the tools necessary to enable genome-wide association studies. Extensive information on the distribution of gene-based single-nucleotide polymorphisms (SNPs) and linkage disequilibrium (LD) patterns across the genome is required in order to choose markers for efficient implementation of this approach. To obtain such information, we have genotyped a large Japanese cohort for SNPs identified by systematic resequencing of more than 14 000 autosomal… CONTINUE READING
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