Variation of codons 1961 and 2177 of the Stargardt disease gene is not associated with age-related macular degeneration.

@article{Guymer2001VariationOC,
  title={Variation of codons 1961 and 2177 of the Stargardt disease gene is not associated with age-related macular degeneration.},
  author={Robyn H. Guymer and Elise Heon and Andrew J. Lotery and Francis L. Munier and Daniel F Schorderet and Paul N Baird and Robina McNeil and Hilary Haines and Val C. Sheffield and Edwin M. Stone},
  journal={Archives of ophthalmology},
  year={2001},
  volume={119 5},
  pages={745-51}
}
OBJECTIVES To investigate the role of 2 specific alleles of the Stargardt disease gene (ABCA4) in the pathogenesis of age-related macular degeneration (AMD). Secondary objectives were to investigate differences in frequency of the G1961E allele in selected ethnic groups as well as to examine the segregation of both G1961E and D2177N alleles in 5 multiplex families with AMD. METHODS Five hundred forty-four patients with AMD and 689 controls were ascertained from 3 continents. Blood samples… CONTINUE READING
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