Variation of MDR proteins expression and activity levels according to clinical status and evolution of CML patients.

@article{Vasconcelos2011VariationOM,
  title={Variation of MDR proteins expression and activity levels according to clinical status and evolution of CML patients.},
  author={Flavia da Cunha Vasconcelos and Karina Lani Silva and Paloma Silva de Souza and Luiz Felipe R Silva and Arthur Moellmann-Coelho and Claudete Esteves Klumb and Raquel Ciuvalschi Maia},
  journal={Cytometry. Part B, Clinical cytometry},
  year={2011},
  volume={80 3},
  pages={
          158-66
        }
}
The involvement of the multidrug resistance (MDR) mediated by ABC transporter proteins P-glycoprotein (Pgp) and multidrug resistance-associated protein-1 (MRP1) overexpressions in patients with chronic myeloid leukemia (CML) are not completely understood. Pgp and MRP1 expressions and activity were analyzed in samples from 158 patients with chronic myeloid leukemia (CML). Using flow cytometry, Pgp expression was more frequently observed in early chronic (P = 0.00) and in advanced (P = 0.02) CML… CONTINUE READING

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