Variation in the uncoupling protein 2 and 3 genes and human performance.

  title={Variation in the uncoupling protein 2 and 3 genes and human performance.},
  author={Sukhbir S. Dhamrait and Alun G. Williams and Stephen H. Day and James Robert Anthony Skipworth and John W. Payne and Michael World and Steve E Humphries and Hugh E. Montgomery},
  journal={Journal of applied physiology},
  volume={112 7},
Uncoupling proteins 2 and 3 (UCP2 and UCP3) may negatively regulate mitochondrial ATP synthesis and, through this, influence human physical performance. However, human data relating to both these issues remain sparse. Examining the association of common variants in the UCP3/2 locus with performance phenotypes offers one means of investigation. The efficiency of skeletal muscle contraction, delta efficiency (DE), was assessed by cycle ergometry in 85 young, healthy, sedentary adults both before… CONTINUE READING


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A significant portion of mitochondrial proton leak in intact thymocytes depends on expression of UCP2.

Proceedings of the National Academy of Sciences of the United States of America • 2002
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