Variation in the timing of puberty: clinical spectrum and genetic investigation.

  title={Variation in the timing of puberty: clinical spectrum and genetic investigation.},
  author={Mark R. Palmert and Paul A Boepple},
  journal={The Journal of clinical endocrinology and metabolism},
  volume={86 6},
Human puberty begins with the reemergence of GnRH secretion from its relative quiescence during childhood, activating a cascade of pituitary-gonadal maturation. This transition begins across a wide range of ages, and the rate of subsequent sexual maturation can be quite varied. The factors that regulate the hypothalamic-pituitary-gonadal axis and modulate the timing of puberty remain elusive, but it is clear that some regulation is under genetic control. Here, we discuss how new advances in… CONTINUE READING

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