Variation in the myosin light chain kinase gene is associated with development of acute lung injury after major trauma*

@article{Christie2008VariationIT,
  title={Variation in the myosin light chain kinase gene is associated with development of acute lung injury after major trauma*},
  author={Jason D. Christie and Shwu-Fan Ma and Richard Aplenc and Mingyao Li and Paul N. Lanken and Chirag V. Shah and Barry D. Fuchs and Steven M. Albelda and Carlos Flores and Joe G.N. Garcia},
  journal={Critical Care Medicine},
  year={2008},
  volume={36},
  pages={2794-2800}
}
Background:Single nucleotide polymorphisms in the myosin light chain kinase (MYLK) gene have been implicated in the risk of sepsis-related acute lung injury and asthma. MYLK encodes protein isoforms involved in multiple components of the inflammatory response, including apoptosis, vascular permeability, and leukocyte diapedesis. We tested the association of MYLK gene variation in the development of acute lung injury in major trauma patients. Methods:We conducted a prospective cohort study of… 

Myosin light chain kinase gene and acute lung injury in trauma and sepsis: opposite effects but confirmatory.

  • M. Gong
  • Medicine
    Critical care medicine
  • 2008
This study has a number of notable strengths, including the prospective cohort design and the daily screening of all patients are less susceptible to selection bias and misclassification of ALI, and the possibility of effect modification by the type of risk factor predisposing to ALI and the effect of MYLK genotype on ALI/ARDS susceptibility.

Genetic variation in MYLK and lung injury in children and adults with community-acquired pneumonia*

  • Rebecca A RussellM. Quasney M. Dahmer
  • Medicine, Biology
    Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
  • 2010
No association between the selected single nucleotide polymorphisms in the myosin light chain kinase gene and either the need for positive-pressure ventilation or the development of acute lung injury/acute respiratory distress syndrome was observed in children with community-acquired pneumonia.

Epigenetic contribution of the myosin light chain kinase gene to the risk for acute respiratory distress syndrome

Novel variants in the PRDX6 Gene and the risk of Acute Lung Injury following major trauma

This study revealed novel SNPs within the PRDX6 gene and its 5' and 3' flanking regions via direct sequencing, and tested association with ALI following major trauma.

ANGPT2 genetic variant is associated with trauma-associated acute lung injury and altered plasma angiopoietin-2 isoform ratio.

An ANGPT2 region is associated with both ALI and variation in plasma angiopoietin-2 isoforms, and characterization of the variant isoform and its genetic regulation may yield important insights about ALI pathogenesis and susceptibility.

Genetic and epigenetic regulation of the non-muscle myosin light chain kinase isoform by lung inflammatory factors and mechanical stress

Findings indicate nmMYLK transcriptional regulation by clinically relevant inflammatory factors and ARDS-associated nmmyLK promoter variants are consistent with nmMLCK as a therapeutic target in severe inflammatory disorders.

Myosin light chain kinase (MYLK) coding polymorphisms modulate human lung endothelial cell barrier responses via altered tyrosine phosphorylation, spatial localization, and lamellipodial protrusions

Qualifiable cell immunofluorescence assays suggest that ARDS/severe asthma-associated MYLK SNPs functionally influence vascular barrier-regulatory cytoskeletal responses via direct alterations in the levels of nmMLCK tyrosine phosphorylation, spatial localization, and lamellipodial protrusions.

Inflammation and Immune-Related Candidate Gene Associations with Acute Lung Injury Susceptibility and Severity: A Validation Study

These associations provide further evidence that genetic factors in genes related to immunity and inflammation contribute to ALI pathogenesis and for SNPs in IL8, MBL2, NFE2L2 and NAMPT with severity in ALI outcomes.

Genome Wide Association Identifies PPFIA1 as a Candidate Gene for Acute Lung Injury Risk Following Major Trauma

This study supports the feasibility of future multi-center GWA investigations of ALi risk, and identifies PPFIA1 as a potential functional candidate ALI risk gene for future research.
...

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