Variation in the lipoprotein receptor-related protein, alpha2-macroglobulin and lipoprotein receptor-associated protein genes in relation to plasma lipid levels and risk of early myocardial infarction.

@article{Gonzlez2002VariationIT,
  title={Variation in the lipoprotein receptor-related protein, alpha2-macroglobulin and lipoprotein receptor-associated protein genes in relation to plasma lipid levels and risk of early myocardial infarction.},
  author={Pelayo Gonz{\'a}lez and Ruth Alvarez and J Rodr{\'i}guez Reguero and Alberto Batalla and V. Gonz{\'a}lez {\'A}lvarez and Arturo Cortina and Gustavo Iglesias Cubero and M{\'o}nica Garc{\'i}a-Castro and Eliecer Coto},
  journal={Coronary artery disease},
  year={2002},
  volume={13 5},
  pages={251-4}
}
BACKGROUND The lipoprotein receptor-related protein (LRP) is an endocytic receptor for several ligands, such as alpha2-macroglobulin (alpha2 M) and apolipoprotein E. LRP is involved in the clearance of lipids from the bloodstream and is expressed in the atherosclerotic plaque. The LRP-associated protein (LRPAP in humans, RAP in mice) acts as a chaperone protein, stabilizing the nascent LRP peptide in the endoplasmic reticulum and Golgi complex. In mice, the amount of LRP activity was modulated… CONTINUE READING
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