Variation in the interleukin 4-receptor alpha gene confers susceptibility to asthma and atopy in ethnically diverse populations.

  title={Variation in the interleukin 4-receptor alpha gene confers susceptibility to asthma and atopy in ethnically diverse populations.},
  author={Carole Ober and Stephanie A. Leavitt and Anya Tsalenko and Timothy D. Howard and D M Hoki and Rolf Daniel and Dina L Newman and Xiaolin Wu and Rodney Parry and Lucille A. Lester and Julian Solway and Malcolm Nolan Blumenthal and Richard L. King and Jiujin Xu and Deborah A. Meyers and Eugene Bleecker and Nancy J. Cox},
  journal={American journal of human genetics},
  volume={66 2},
After a genomewide screen in the Hutterites was completed, the IL4RA gene was examined as the 16p-linked susceptibility locus for asthma and atopy. Seven known variants and one novel variant, representing all nonsynonymous substitutions in the mature protein, were examined in the Hutterites; on the basis of studies in the Hutterites, outbred white, black, and Hispanic families were genotyped for selected markers. All population samples showed evidence of association to atopy or to asthma (P… CONTINUE READING

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