Variation in the interleukin 4-receptor alpha gene confers susceptibility to asthma and atopy in ethnically diverse populations.

@article{Ober2000VariationIT,
  title={Variation in the interleukin 4-receptor alpha gene confers susceptibility to asthma and atopy in ethnically diverse populations.},
  author={Carole Ober and Stephanie A. Leavitt and Anya Tsalenko and Timothy D. Howard and D M Hoki and Rolf Daniel and Dina L Newman and Xiaolin Wu and Rodney Parry and Lucille A. Lester and Julian Solway and Malcolm Nolan Blumenthal and Richard L. King and Jiujin Xu and Deborah A. Meyers and Eugene Bleecker and Nancy J. Cox},
  journal={American journal of human genetics},
  year={2000},
  volume={66 2},
  pages={517-26}
}
After a genomewide screen in the Hutterites was completed, the IL4RA gene was examined as the 16p-linked susceptibility locus for asthma and atopy. Seven known variants and one novel variant, representing all nonsynonymous substitutions in the mature protein, were examined in the Hutterites; on the basis of studies in the Hutterites, outbred white, black, and Hispanic families were genotyped for selected markers. All population samples showed evidence of association to atopy or to asthma (P… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.

Explore Further: Topics Discussed in This Paper

Citations

Publications citing this paper.
Showing 1-10 of 80 extracted citations

Pathogenicity of a disease-associated human IL-4 receptor allele in experimental asthma

The Journal of experimental medicine • 2009
View 10 Excerpts
Highly Influenced

The genetics of atopic dermatitis: recent findings and future options

Journal of Molecular Medicine • 2005
View 5 Excerpts
Highly Influenced

References

Publications referenced by this paper.
Showing 1-10 of 32 references

Common polymorphisms in the coding part of the IL4-receptor gene.

Biochemical and biophysical research communications • 1997
View 11 Excerpts
Highly Influenced

The TDT and other family-based tests for linkage disequilibrium and association.

American journal of human genetics • 1996
View 10 Excerpts
Highly Influenced

Comparative DNA sequencing by denaturing high-performance liquid chromatography (DHPLC)

PJ Oefner, PA Underhill
Am J Hum Genet Suppl • 1995
View 4 Excerpts
Highly Influenced

Haplotyping algorithms. In: Speed TP, Waterman MS (eds) IMA volumes in mathematics and its applications, vol 81

E Sobel, K Lange, J O’Connell, D Weeks
1996
View 2 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…