Variation in the genes encoding vesicular monoamine transporter 2 and beta-1 adrenergic receptor and antidepressant treatment outcome

  title={Variation in the genes encoding vesicular monoamine transporter 2 and beta-1 adrenergic receptor and antidepressant treatment outcome},
  author={J. Crowley and R. Lipsky and I. Lucki and W. Berrettini},
  journal={Psychiatric Genetics},
  • J. Crowley, R. Lipsky, +1 author W. Berrettini
  • Published 2008
  • Biology, Medicine
  • Psychiatric Genetics
  • The identification of genetic variants regulating antidepressant response would allow for more individualized, rational, and successful drug treatments. We previously identified a region of mouse chromosome 19 that strongly influences citalopram response in an antidepressant model, the tail suspension test. By virtue of their location in this loci, expression in brain, and involvement in monoamine neurotransmission, we nominated SLC18A2 (encoding vesicular monoamine transporter 2, a.k.a. VMAT2… CONTINUE READING
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