Variation in the frequency of complex forms of mitochondrial DNA in different brain regions of senescent mice

@article{Bulpitt1984VariationIT,
  title={Variation in the frequency of complex forms of mitochondrial DNA in different brain regions of senescent mice},
  author={Ken J Bulpitt and Lajos Pik{\'o}},
  journal={Brain Research},
  year={1984},
  volume={300},
  pages={41-48}
}
It was shown previously that the frequency of an aberrant form of mitochondrial DNA (mtDNA), double-sized circular molecules or circular dimers, increased significantly in the brain of senescent mice, to about 2% versus less than 0.1% in the brain of adult mice. To follow up these observations, we isolated total mtDNA from 6 different brain regions of 29-month-old male BALB/c mice and examined it for the occurrence of circular dimers and other complex forms by electron microscopy. There was a… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-2 of 2 extracted citations

Similar Papers

Loading similar papers…