Variation in the adiponutrin gene influences its expression and associates with obesity.

  title={Variation in the adiponutrin gene influences its expression and associates with obesity.},
  author={Lovisa E. Johansson and Johan Hoffstedt and Hemang Parikh and Emma Carlsson and Martin Wabitsch and Anne-Greth Bondeson and Jan Hedenbro and Hans Tornqvist and Leif Groop and Martin Ridderstr{\aa}le},
  volume={55 3},
Adiponutrin is one of three recently identified adipocyte lipases. Surprisingly, these proteins also retain transacylase activity, a hitherto unknown pathway of triacylglycerol synthesis in the adipocytes. This may enable them to participate in both anabolic and catabolic processes. The adiponutrin gene (ADPN) is downregulated by fasting and upregulated by refeeding, suggesting a role in lipogenesis. Experiments in human adipocytes confirmed that the gene is upregulated in response to insulin… CONTINUE READING


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