Variation in the PDE 4 D Gene and Ischemic Stroke Risk

  title={Variation in the PDE 4 D Gene and Ischemic Stroke Risk},
  author={Steve N Bevan and Martin Dichgans and Andreas Gschwendtner and Gregor Kuhlenbaeumer and E. Bernd Ringelstein and Hugh S. Markus},
Background and Purpose—PDE4D was identified as the first novel gene associated with ischemic stroke risk. Replication studies have produced conflicting results, but many have been small and underpowered. Meta-analysis provides a method to combine this data and determine in a larger sample size whether the association with PDE4D can be replicated. Methods—A meta-analysis of all PDE4D variants investigated in relation to ischemic stroke has been undertaken. Analysis of any variant appearing in 2… CONTINUE READING


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