Variation in sensitizing effect of caffeine in human tumour cell lines after gamma-irradiation.

BACKGROUND AND PURPOSE We have investigated whether the protective role of the G2 checkpoint has increasing importance when the p53-dependent G1 checkpoint is inactivated. MATERIALS AND METHODS We have studied the differential effect of caffeine by clonogenic assays and flow cytometry in three human tumour cell lines with different functionality of p53… (More)