Variation in senescent-dependent lung changes in inbred mouse strains.

  title={Variation in senescent-dependent lung changes in inbred mouse strains.},
  author={Kewu Huang and Wayne Mitzner and Richard Rabold and B. Schofield and Hannah K. Lee and Shyam Biswal and Clarke G. Tankersley},
  journal={Journal of applied physiology},
  volume={102 4},
Previous studies from our laboratories showed lung development differences between inbred strains of mice. In the present study, the C57BL/6J (B6) and DBA/2J (D2) strains were examined for senescent-dependent differences with respect to the lung structure and function. Specifically, we hypothesize that senescent changes in lung vary between strains due to identifiable gene expression differences. Quasi-static pressure-volume curves and respiratory impedance measurements were performed on 2- and… CONTINUE READING
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