Variation in route of microsomal activation of 7,12-dimethylbenz [a]anthracene with substrate concentration +.

Abstract

The nature of the metabolites of 7,12-dimethylbenz[a]anthracene (DMBA) binding to DNA in the presence of Aroclor-induced rat liver microsomes is not affected by the presence or absence of magnesium ions, but is dependent on the concentration of the hydrocarbon. At high concentrations of DMBA, the primary route of metabolic activation is through the K-region… (More)

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