Variation in response of xenografts of colo-rectal carcinoma to chemotherapy.

  title={Variation in response of xenografts of colo-rectal carcinoma to chemotherapy.},
  author={Katarzyna Nowak and Michael J Peckham and G. Gordon Steel},
  journal={British Journal of Cancer},
  pages={576 - 584}
Ten xenograft lines of human colonic and rectal carcinomas have been established in immune-suppressed mice. Mice bearing tumours in the 2nd to 6th passage were treated with maximum tolerated doses of 8 chemotherapeutic agents and tumour growth delay was estimated in terms of the number of volume doubling times gained by the treatment. The average response corresponded to a delay of only about 0.5 doubling times, but some tumour lines showed a good response to some agents. Twenty-three out of… CONTINUE READING


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