Variation in prescribing patterns and therapeutic drug monitoring of intravenous busulfan in pediatric hematopoietic cell transplant recipients.

@article{McCune2013VariationIP,
  title={Variation in prescribing patterns and therapeutic drug monitoring of intravenous busulfan in pediatric hematopoietic cell transplant recipients.},
  author={Jeannine McCune and Kevin Scott Baker and David K. Blough and Alan S Gamis and Meagan J. Bemer and Megan C Kelton-Rehkopf and Laura J Winter and Jeffrey S. Barrett},
  journal={Journal of clinical pharmacology},
  year={2013},
  volume={53 3},
  pages={264-75}
}
Personalizing intravenous (IV) busulfan doses in children using therapeutic drug monitoring (TDM) is an integral component of hematopoietic cell transplant. The authors sought to characterize initial dosing and TDM of IV busulfan, along with factors associated with busulfan clearance, in 729 children who underwent busulfan TDM from December 2005 to December 2008. The initial IV busulfan dose in children weighing ≤12 kg ranged 4.8-fold, with only 19% prescribed the package insert dose of 1.1 mg… CONTINUE READING
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