Variation in physicochemical properties of the hypervariable region 1 during acute and chronic stages of hepatitis C virus infection

@article{Astrakhantseva2011VariationIP,
  title={Variation in physicochemical properties of the hypervariable region 1 during acute and chronic stages of hepatitis C virus infection},
  author={Irina V. Astrakhantseva and David S. Campo and Aufra Araujo and Chong-Gee Teo and Yuri Khudyakov and Saleem Kamili},
  journal={2011 IEEE International Conference on Bioinformatics and Biomedicine Workshops (BIBMW)},
  year={2011},
  pages={72-78}
}
Differentiation between acute and chronic HCV infections is clinically important given that early treatment of infected patients leads to high rates of sustained virological response. Analysis of HVR1 sequences (n=2179) from samples obtained from patients with acute (n=49) and chronic (n=102) HCV infections showed that intra-host HVR1 diversity was 1.8 times higher in patients with chronic than acute infection. Analysis of molecular variance showed significant differences between sequences from… CONTINUE READING

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