Variation in key genes of serotonin and norepinephrine function predicts gamma-band activity during goal-directed attention.

@article{Enge2014VariationIK,
  title={Variation in key genes of serotonin and norepinephrine function predicts gamma-band activity during goal-directed attention.},
  author={S{\"o}ren Enge and Monika Fleischhauer and Klaus-Peter Lesch and Andreas Reif and Alexander Strobel},
  journal={Cerebral cortex},
  year={2014},
  volume={24 5},
  pages={1195-205}
}
Recent evidence shows that genetic variations in key regulators of serotonergic (5-HT) signaling explain variance in executive tasks, which suggests modulatory actions of 5-HT on goal-directed selective attention as one possible underlying mechanism. To investigate this link, 130 volunteers were genotyped for the 5-HT transporter gene-linked polymorphic region (5-HTTLPR) and for a variation (TPH2-703 G/T) of the TPH2 gene coding for the rate-limiting enzyme of 5-HT synthesis in the brain… CONTINUE READING