Variation in inflammatory markers and glycemic parameters after 12 months of exenatide plus metformin treatment compared with metformin alone: a randomized placebo-controlled trial.

@article{Derosa2013VariationII,
  title={Variation in inflammatory markers and glycemic parameters after 12 months of exenatide plus metformin treatment compared with metformin alone: a randomized placebo-controlled trial.},
  author={Giuseppe Derosa and Ivano G Franzetti and Fabrizio Querci and Anna Carbone and Leonardina Ciccarelli and Mario Nello Piccinni and Elena Fogari and Pamela Maffioli},
  journal={Pharmacotherapy},
  year={2013},
  volume={33 8},
  pages={817-26}
}
STUDY OBJECTIVE To evaluate the effects of exenatide on some inflammatory markers and to quantify the effect of exenatide on β-cell function. DESIGN A randomized, double-blind, placebo-controlled trial. SETTING Seven hospitals in Italy. PATIENTS A total of 174 white treatment-naive adults with type 2 diabetes and a glycated hemoglobin (HbA(1c)) level higher than 7.5%. INTERVENTION After an open-label run-in period of 8 ± 2 months with metformin, patients were randomized to take… CONTINUE READING

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