Variation in complement factor 3 is associated with risk of age-related macular degeneration

@article{Maller2007VariationIC,
  title={Variation in complement factor 3 is associated with risk of age-related macular degeneration},
  author={Julian B. Maller and Jesen A. Fagerness and Robyn C Reynolds and Benjamin M. Neale and Mark J. Daly and Johanna M. Seddon},
  journal={Nature Genetics},
  year={2007},
  volume={39},
  pages={1200-1201}
}
The association of variants in complement factors H and B with age-related macular degeneration has led to more intense genetic and functional analysis of the complement pathway. We identify a nonsynonymous coding change in complement factor 3 that is strongly associated with risk of age-related macular degeneration in a large case-control sample. 
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Rare Variants in the Functional Domains of Complement Factor H Are Associated With Age-Related Macular Degeneration.
TLDR
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