Variation in adenovirus receptor expression and adenovirus vector-mediated transgene expression at defined stages of the cell cycle.

@article{Seidman2001VariationIA,
  title={Variation in adenovirus receptor expression and adenovirus vector-mediated transgene expression at defined stages of the cell cycle.},
  author={Michael A. Seidman and Shirley M Hogan and Rebecca L. Wendland and Stefan Worgall and Ronald G. Crystal and Philip L. Leopold},
  journal={Molecular therapy : the journal of the American Society of Gene Therapy},
  year={2001},
  volume={4 1},
  pages={
          13-21
        }
}
Detailed investigations have addressed the infection pathway of recombinant adenovirus (Ad) gene transfer vectors, but little attention has been paid to the influence of cell physiology on the outcome of Ad infection. Based on observations that Ad infection of clonal cell populations show cell-to-cell variability in the extent of capsid binding, we hypothesized that the cell cycle may influence the outcome of Ad infection. To address this hypothesis, we evaluated Ad association with cells in… CONTINUE READING
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