Variation in Tolerance Dose Requirements as related to Heterogeneity of the Immune Response

Abstract

BY varying widely the dose of a protein antigen it is possible, in a given system, to vary the response to this antigen from formation of both IgM and IgG antibodies (in the medium dose range1) to lack of formation of either type (repeated massive doses). In between, a regimen of antigen administration can be found which stimulates the formation of IgG and… (More)
DOI: 10.1038/2131017a0

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