Variation in Streptococcus pyogenes NAD+ glycohydrolase is associated with tissue tropism.

@article{Riddle2010VariationIS,
  title={Variation in Streptococcus pyogenes NAD+ glycohydrolase is associated with tissue tropism.},
  author={David J. Riddle and Debra E. Bessen and Michael G Caparon},
  journal={Journal of bacteriology},
  year={2010},
  volume={192 14},
  pages={
          3735-46
        }
}
Streptococcus pyogenes is an important pathogen that causes a variety of diseases. The most common infections involve the throat (pharyngitis) or skin (impetigo); however, the factors that determine tissue tropism and severity are incompletely understood. The S. pyogenes NAD(+) glycohydrolase (SPN) is a virulence factor that has been implicated in contributing to the pathogenesis of severe infections. However, the role of SPN in determining the bacterium's tissue tropism has not been evaluated… CONTINUE READING

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