Variation in RAD51 details a hub of functions: opportunities to advance cancer diagnosis and therapy.

  title={Variation in RAD51 details a hub of functions: opportunities to advance cancer diagnosis and therapy.},
  author={Nick Ll van der Zon and Roland Kanaar and Claire Wyman},
Loss of genome stability is one of the hallmarks of the enabling characteristics of cancer development. Homologous recombination is a DNA repair process that often breaks down as a prelude to developing cancer. Conversely, homologous recombination can be the Achilles' heel in common anti-cancer therapies, which are effective by inducing irreparable DNA damage. Here, we review recent structural and functional studies of RAD51, the protein that catalyzes the defining step of homologous… 

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