Variation in ITGB3 is associated with asthma and sensitization to mold allergen in four populations.

@article{Weiss2005VariationII,
  title={Variation in ITGB3 is associated with asthma and sensitization to mold allergen in four populations.},
  author={Lauren A Weiss and Lucille A. Lester and James E Gern and Raoul L Wolf and Rodney Parry and Robert F. Lemanske and Julian Solway and Carole Ober},
  journal={American journal of respiratory and critical care medicine},
  year={2005},
  volume={172 1},
  pages={67-73}
}
RATIONALE Recent genetic studies have implicated integrins in asthma and atopy susceptibility. We therefore evaluated the integrin-beta3 gene (ITGB3), an integrin gene within an asthma linkage peak on chromosome 17, as a candidate for susceptibility to asthma- and atopy-related phenotypes. METHODS AND MEASUREMENTS We genotyped and performed association tests on 19 single nucleotide polymorphisms in ITGB3 in the Hutterites, a founder population, and in three outbred replication populations… CONTINUE READING
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