Variation in Homeodomain DNA Binding Revealed by High-Resolution Analysis of Sequence Preferences

@article{Berger2008VariationIH,
  title={Variation in Homeodomain DNA Binding Revealed by High-Resolution Analysis of Sequence Preferences},
  author={Michael F. Berger and Gwenael Badis and Andrew R. Gehrke and Shaheynoor Talukder and Anthony A. Philippakis and Lourdes Pex00F1a-Castillo and Trevis M. Alleyne and Sanie Mnaimneh and Olga B. Botvinnik and Esther T. Chan and Faiqua Khalid and Wen Zhang and Daniel E. Newburger and Savina Andonova Jaeger and Quaid Morris and Martha L. Bulyk and Timothy R. Hughes},
  journal={Cell},
  year={2008},
  volume={133},
  pages={1266-1276}
}
Most homeodomains are unique within a genome, yet many are highly conserved across vast evolutionary distances, implying strong selection on their precise DNA-binding specificities. We determined the binding preferences of the majority (168) of mouse homeodomains to all possible 8-base sequences, revealing rich and complex patterns of sequence specificity and showing that there are at least 65 distinct homeodomain DNA-binding activities. We developed a computational system that successfully… CONTINUE READING
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