Variation in Gastrointestinal Transit of Pharmaceutical Dosage Forms in Healthy Subjects

  title={Variation in Gastrointestinal Transit of Pharmaceutical Dosage Forms in Healthy Subjects},
  author={Alastair J. Coupe and Stanley S. Davis and Ian R. Wilding},
  journal={Pharmaceutical Research},
The variability in the gastrointestinal transit of a multiple-unit and single-unit dosage form was investigated following a light breakfast in six, healthy, male volunteers after repeated weekly administration. The dosage forms were labeled with gamma-emitting radionuclides and the transit of the formulations was monitored on 4 separate study days using the technique of dual-isotope gamma scintigraphy. Gastric emptying times and small intestinal transit times were calculated and compared… CONTINUE READING


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