Variation in Dietary Salt Intake Induces Coordinated Dynamics of Monocyte Subsets and Monocyte-Platelet Aggregates in Humans: Implications in End Organ Inflammation

@inproceedings{Zhou2013VariationID,
  title={Variation in Dietary Salt Intake Induces Coordinated Dynamics of Monocyte Subsets and Monocyte-Platelet Aggregates in Humans: Implications in End Organ Inflammation},
  author={Xin Zhou and Ling Zhang and Wen-jie Ji and Fei Yuan and Zhao-Zeng Guo and Bo Pang and Tao Luo and Xing Liu and Wen-cheng Zhang and Tie-min Jiang and Zhuoli Zhang and Yu-ming Li},
  booktitle={PloS one},
  year={2013}
}
BACKGROUND Monocyte activation and tissue infiltration are quantitatively associated with high-salt intake induced target organ inflammation. We hypothesized that high-salt challenge would induce the expansion of CD14++CD16+ monocytes, one of the three monocyte subsets with a pro-inflammatory phenotype, that is associated with target organ inflammation in humans. METHODOLOGY/PRINCIPAL FINDINGS A dietary intervention study was performed in 20 healthy volunteers, starting with a 3-day usual… CONTINUE READING
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