Variation in CYP2A6 and tobacco dependence throughout adolescence and in young adult smokers.

@article{Chenoweth2016VariationIC,
  title={Variation in CYP2A6 and tobacco dependence throughout adolescence and in young adult smokers.},
  author={Meghan J Chenoweth and Marie-Pierre Sylvestre and Gis{\`e}le A. Contreras and Maria Novalen and Jennifer Lee O'Loughlin and Rachel F. Tyndale},
  journal={Drug and alcohol dependence},
  year={2016},
  volume={158},
  pages={139-46}
}
BACKGROUND Smoking is influenced by genetic factors including variation in CYP2A6 and CYP2B6, which encode nicotine-metabolizing enzymes. In early adolescence, CYP2A6 slow nicotine metabolism was associated with higher dependence acquisition, but reduced cigarette consumption. Here we extend this work by examining associations of CYP2A6 and CYP2B6 with tobacco dependence acquisition in a larger sample of smokers followed throughout adolescence. METHODS White participants from the Nicotine… CONTINUE READING
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