Variants within the MMP3 gene are associated with Achilles tendinopathy: possible interaction with the COL5A1 gene.

@article{Raleigh2009VariantsWT,
  title={Variants within the MMP3 gene are associated with Achilles tendinopathy: possible interaction with the COL5A1 gene.},
  author={Stuart M. Raleigh and Lize van der Merwe and William John Ribbans and Roger K. W. Smith and M P Schwellnus and Malcolm Collins},
  journal={British journal of sports medicine},
  year={2009},
  volume={43 7},
  pages={514-20}
}
OBJECTIVES Sequence variation within the COL5A1 and TNC genes are known to associate with Achilles tendinopathy. The primary aim of this case-control genetic association study was to investigate whether variants within the matrix metalloproteinase 3 (MMP3) gene also contributed to both Achilles tendinopathy and Achilles tendon rupture in a Caucasian population. A secondary aim was to establish whether variants within the MMP3 gene interacted with the COL5A1 rs12722 variant to raise risk of… CONTINUE READING
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