Variants on chromosome 9p21.3 correlated with ANRIL expression contribute to stroke risk and recurrence in a large prospective stroke population.

@article{Zhang2012VariantsOC,
  title={Variants on chromosome 9p21.3 correlated with ANRIL expression contribute to stroke risk and recurrence in a large prospective stroke population.},
  author={Weili Zhang and Yan Chen and Peng Liu and Jingzhou Chen and Lei Song and Yue Tang and Yuyao Wang and Jibin Liu and Frank B Hu and Rutai Hui},
  journal={Stroke},
  year={2012},
  volume={43 1},
  pages={14-21}
}
BACKGROUND AND PURPOSE ANRIL encodes a long antisense noncoding RNA in the INK4 locus. Although ANRIL has been proven to be associated with coronary heart disease, its roles in stroke are inconsistent, and sparse data are available regarding hemorrhagic stroke. METHODS A Chinese case-control study was conducted, comprising 1657 cases (724 atherothrombosis, 466 lacunar infarction, and 462 hemorrhagic strokes) and 1664 controls. Stroke patients were prospectively followed-up for a median of 4.5… CONTINUE READING
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