Variants of the interleukin-10 promoter gene are associated with obesity and insulin resistance but not type 2 diabetes in caucasian italian subjects.

@article{Scarpelli2006VariantsOT,
  title={Variants of the interleukin-10 promoter gene are associated with obesity and insulin resistance but not type 2 diabetes in caucasian italian subjects.},
  author={Daniela Scarpelli and Marina Cardellini and Francesco Andreozzi and Emanuela Laratta and Marta Letizia Hribal and Maria Adelaide Marini and Vittorio Tassi and Renato Lauro and Francesco Perticone and Giorgio Sesti},
  journal={Diabetes},
  year={2006},
  volume={55 5},
  pages={1529-33}
}
Interleukin (IL)-10 is a major anti-inflammatory cytokine that has been associated with obesity and type 2 diabetes. The three polymorphisms -1082G/A, -819C/T, and -592C/A in the IL10 promoter were reported to influence IL10 transcription. We investigated whether these polymorphisms were associated with type 2 diabetes and related traits in a cohort of Italian Caucasians comprising 551 type 2 diabetic and 1,131 control subjects. The -819C/T and -592C/A polymorphisms were in perfect linkage… CONTINUE READING
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Differential effects of interleukin-6 and -10 on skeletal muscle and liver insulin action in vivo

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