Variants of the hK2 protein gene (KLK2) are associated with serum hK2 levels and predict the presence of prostate cancer at biopsy.

Abstract

PURPOSE Increased levels of serum human kallikrein-2 (hK2) and an hK2 gene (KLK2) variant are positively associated for prostate cancer, but the relationships between them remain unclear. We examined five variants of the KLK2 gene to further define its relevance to prostate cancer susceptibility and hK2 levels. EXPERIMENTAL DESIGN We genotyped 645 men… (More)

Topics

7 Figures and Tables

Cite this paper

@article{Nam2006VariantsOT, title={Variants of the hK2 protein gene (KLK2) are associated with serum hK2 levels and predict the presence of prostate cancer at biopsy.}, author={Robert K. Nam and William Zhang and Laurence H. Klotz and John Trachtenberg and Michael A. S. Jewett and Joan Sweet and Ants Toi and Seamus J Teahan and Vasundara Venkateswaran and Linda Marilyn Sugar and Andrew Loblaw and Kathy A. Siminovitch and Steven A Narod}, journal={Clinical cancer research : an official journal of the American Association for Cancer Research}, year={2006}, volume={12 21}, pages={6452-8} }