Variants of the MTHFR gene and susceptibility to acute lymphoblastic leukemia in children: a synthesis of genetic association studies.

@article{Zintzaras2012VariantsOT,
  title={Variants of the MTHFR gene and susceptibility to acute lymphoblastic leukemia in children: a synthesis of genetic association studies.},
  author={Elias Zintzaras and Chrysoula Doxani and Paraskevi Rodopoulou and G Bakalos and Dimitris C Ziogas and Panayiotis D. Ziakas and Michalis Voulgarelis},
  journal={Cancer epidemiology},
  year={2012},
  volume={36 2},
  pages={169-76}
}
BACKGROUND Acute lymphoblastic leukemia (ALL) is a complex disease with genetic background. The genetic association studies (GAS) that investigated the association between ALL and the MTHFR C677T and A1298C gene variants have produced contradictory or inconclusive results. MATERIALS AND METHODS In order to decrease the uncertainty of estimated genetic risk effects, a meticulous meta-analysis of published GAS related the variants in the MTFHR gene with susceptibility to ALL was conducted. The… CONTINUE READING
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