Variants of the CD40 ligand gene are not associated with increased susceptibility to tuberculosis in West Africa

@article{Campbell2003VariantsOT,
  title={Variants of the CD40 ligand gene are not associated with increased susceptibility to tuberculosis in West Africa},
  author={Sarah J. Campbell and Pardis C Sabeti and Katherine R Fielding and Jackson S. Sillah and Boubacar Bah and Per Gustafson and Kebba Manneh and Ida Marie Lisse and Giorgio Sirugo and Richard John Bellamy and Steve Bennett and Peter Aaby and K W Mcadam and Oumou Bah-Sow and Christian Lienhardt and Adrian V S Hill},
  journal={Immunogenetics},
  year={2003},
  volume={55},
  pages={502-507}
}
Evidence for linkage between tuberculosis and human chromosomal region Xq26 has previously been described. The costimulatory molecule CD40 ligand, encoded by TNFSF5 and located at Xq26.3, is a promising positional candidate. Interactions between CD40 ligand and CD40 are involved in the development of humoral- and cell-mediated immunity, as well as the activation of macrophages, which are the primary host and effector cells for Mycobacterium tuberculosis. We hypothesised that common variation… CONTINUE READING
8 Citations
26 References
Similar Papers

References

Publications referenced by this paper.
Showing 1-10 of 26 references

Association of a polymorphism in the P2X7 gene with tuberculosis in a Gambian population

  • CM Li, SJ Campbell, +4 authors D Lammas
  • J Infect Dis
  • 2002
2 Excerpts

Similar Papers

Loading similar papers…