Variants of core histones and their roles in cell fate decisions, development and cancer

@article{Buschbeck2017VariantsOC,
  title={Variants of core histones and their roles in cell fate decisions, development and cancer},
  author={Marcus Buschbeck and Sandra B Hake},
  journal={Nature Reviews Molecular Cell Biology},
  year={2017},
  volume={18},
  pages={299-314}
}
Histone variants endow chromatin with unique properties and show a specific genomic distribution that is regulated by specific deposition and removal machineries. These variants — in particular, H2A.Z, macroH2A and H3.3 — have important roles in early embryonic development, and they regulate the lineage commitment of stem cells, as well as the converse process of somatic cell reprogramming to pluripotency. Recent progress has also shed light on how mutations, transcriptional deregulation and… 
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TLDR
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The Histone H3 Family and Its Deposition Pathways.
TLDR
This chapter introduces the organization of the genome in chromatin with a focus on the basic unit, the nucleosome, which contains histones as the major protein component and reviews current knowledge on the histone H3 family and its variants.
Chromatin regulation and dynamics in stem cells.
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TLDR
This review focuses on the chaperone proteins of H 3.1 and H3.3, including structure, regulation, as well as their oncogenic and tumor suppressive functions in tumorigenesis.
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