Variants of C1GALT1 gene are associated with the genetic susceptibility to IgA nephropathy.

@article{Li2007VariantsOC,
  title={Variants of C1GALT1 gene are associated with the genetic susceptibility to IgA nephropathy.},
  author={G-S Li and Hong Zhang and J-C Lv and Yan Shen and Hoau-Yan Wang},
  journal={Kidney international},
  year={2007},
  volume={71 5},
  pages={448-53}
}
IgA nephropathy (IgAN) is a polygenic disorder and the precise role of genetic factors remains elusive. Increasing evidences have implicated the aberrant galactosylation of IgA1 molecules in the pathogenesis of IgAN. The galactosyltransferase, core 1 beta3-Gal-T, and its chaperone, Cosmc, play important roles in beta1,3 glycosylation of IgA1 molecule. A case-control association study was performed to investigate the association between single-nucleotide polymorphisms (SNPs) of C1GALT1 and… CONTINUE READING
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