Variants near TERT and TERC influencing telomere length are associated with high-grade glioma risk

  title={Variants near TERT and TERC influencing telomere length are associated with high-grade glioma risk},
  author={Kyle M. Walsh and Veryan Codd and Ivan V. Smirnov and Terri S Rice and P. Anthony Decker and Helen M. Hansen and Thomas M. Kollmeyer and Matthew L. Kosel and Annette M. Molinaro and Lucie S. McCoy and Paige M. Bracci and Belinda S. Cabriga and Melike Pekmezci and Shichun Zheng and Joseph Wiemels and Alexander R. Pico and Tarik Tihan and Mitchell S. Berger and Susan M. Chang and Michael D. Prados and Daniel H. Lachance and Brian Patrick O’Neill and Hugues Sicotte and Jeanette E. Eckel-Passow and Pim van der Harst and John K. Wiencke and Nilesh J. Samani and R. Brian Jenkins and Margaret R. Wrensch},
  booktitle={Nature Genetics},
Glioma, the most common central nervous system cancer in adults, has poor prognosis. Here we identify a new SNP associated with glioma risk, rs1920116 (near TERC), that reached genome-wide significance (Pcombined = 8.3 × 10−9) in a meta-analysis of genome-wide association studies (GWAS) of high-grade glioma and replication data (1,644 cases and 7,736 controls). This region has previously been associated with mean leukocyte telomere length (LTL). We therefore examined the relationship between… CONTINUE READING
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