Variants in the fetal genome near FLT1 are associated with risk of preeclampsia

@article{McGinnis2017VariantsIT,
  title={Variants in the fetal genome near FLT1 are associated with risk of preeclampsia},
  author={Ralph McGinnis and Valgerdur Steinthorsdottir and N. Williams and Gudmar Thorleifsson and Scott Shooter and Sigr{\'u}n Hjartard{\'o}ttir and Suzannah J. Bumpstead and Lilja Bj{\"o}rk Stef{\'a}nsd{\'o}ttir and Lucy Hildyard and Jon Kristinn Sigurdsson and John P. Kemp and Gabriela Brettas Silva and Liv Cecilie Vestrheim Thomsen and Tiina J{\"a}{\"a}skel{\"a}inen and Eero Kajantie and Sally Chappell and Noor A. Kalsheker and Ashley Moffett and Susan E. Hiby and Wai Kwong Lee and Sandosh Padmanabhan and Nigel A B Simpson and Vivien A Dolby and Eleonora Staines-Urias and Stephanie M. Engel and Anita Haugan and Lill Trogstad and Gulnara Svyatova and Nodira Zakhidova and Dilbar K. Najmutdinova and Anna F. Dominiczak and H{\aa}kon Kristian Gjessing and Juan Pablo Casas and Frank Dudbridge and James J. Walker and Fiona Broughton Pipkin and Unnur Thorsteinsd{\'o}ttir and Reynir T Geirsson and Deborah A. Lawlor and Ann-Charlotte Iversen and Per Minor Magnus and Hannele Laivuori and K{\'a}ri Stef{\'a}nsson and Linda Morgan},
  journal={Nature Genetics},
  year={2017},
  volume={49},
  pages={1255-1260}
}
Preeclampsia, which affects approximately 5% of pregnancies, is a leading cause of maternal and perinatal death. The causes of preeclampsia remain unclear, but there is evidence for inherited susceptibility. Genome-wide association studies (GWAS) have not identified maternal sequence variants of genome-wide significance that replicate in independent data sets. We report the first GWAS of offspring from preeclamptic pregnancies and discovery of the first genome-wide significant susceptibility… Expand
Genetic predisposition to preeclampsia is conferred by fetal DNA variants near FLT1, a gene involved in the regulation of angiogenesis.
TLDR
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