Variants in the FFAR1 Gene Are Associated with Beta Cell Function

  title={Variants in the FFAR1 Gene Are Associated with Beta Cell Function},
  author={Martins Kalis and Per Lev{\'e}en and Valeriya Lyssenko and Peter Almgren and Leif Groop and Corrado Maria Cilio},
  journal={PLoS ONE},
  pages={3 - 13}
BACKGROUND The FFAR1 receptor is expressed mainly in pancreatic beta cells and is activated by medium to long chain free fatty acids (FFAs), as well as by thiazolidinediones, resulting in elevated Ca(2+) concentrations and promotion of insulin secretion. These properties suggest that FFAR1 could be a mediator of lipotoxicity and a potential candidate gene for Type 2 diabetes (T2D). We therefore investigated whether variations at the FFAR1 locus are associated with T2D and beta cell function… CONTINUE READING
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