Variants in KITLG predispose to testicular germ cell cancer independently from spermatogenic function.

@article{Ferlin2012VariantsIK,
  title={Variants in KITLG predispose to testicular germ cell cancer independently from spermatogenic function.},
  author={Alberto Ferlin and Manuel Pengo and Damiano Pizzol and Umberto Carraro and Anna Chiara Frigo and C Foresta},
  journal={Endocrine-related cancer},
  year={2012},
  volume={19 1},
  pages={101-8}
}
Epidemiological data suggest an association and a common pathogenetic link between male infertility and testicular germ cell tumor (TGCT) development. Genome-wide studies identified that TGCT susceptibility is associated with KITLG (c-KIT ligand), which regulates the formation of primordial germ cells, from which TGCT is believed to arise and spermatogenesis develops. In this study, we analyzed the link between KITLG, TGCT, and spermatogenic disruption by performing an association study between… CONTINUE READING

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