Variants in ANRIL gene correlated with its expression contribute to myocardial infarction risk

@inproceedings{Cheng2017VariantsIA,
  title={Variants in ANRIL gene correlated with its expression contribute to myocardial infarction risk},
  author={Jie Cheng and Meng-yun Cai and Yu-ning Chen and Zhi-Cheng Li and Sai-sai Tang and Xi-li Yang and Can Chen and Xinguang Liu and Xing-Dong Xiong},
  booktitle={Oncotarget},
  year={2017}
}
ANRIL (antisense non-coding RNA in the INK4 locus), located at the 9p21.3 locus, has been known to be closely associated with the risk of coronary artery disease (CAD). To date, studies of the 9p21.3 variants on CAD risk mainly focus on the non-coding region of ANRIL. However, the biological significance of the variants on ANRIL promoter and exons is still unknown. Here we investigate whether the variants on ANRIL promoter and exons have an effect on myocardial infarction (MI) risk, and further… CONTINUE READING
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  • S Kathiresan, BF Voight, +9 authors MP Reilly
  • Nat Genet
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Highly Influential
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